As good Catholic men, the Knights of Columbus are staunch supporters of Pro-Life activities.
- National Right to Life
- March for Life – sponsor of the annal National March for Life, which in 2025 is on January 24 in Washington, DC.
- South Carolina Citizens for Life – sponsor of the Proudly Pro-Life Weekend, which in 2025 is on January 10 (dinner) and 11 (march and rally) in Columbia, SC.
- Regional and local Right to Life Activities